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Home - Products - GPCR/G Protein - Bradykinin Receptor - Sar-[D-Phe8]-des-Arg9-Bradykinin

Sar-[D-Phe8]-des-Arg9-Bradykinin

CAS No. 126959-88-4

Sar-[D-Phe8]-des-Arg9-Bradykinin( —— )

Catalog No. M30744 CAS No. 126959-88-4

Potent and selective bradykinin B1 receptor agonist (EC50 = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cleavage. Exhibits hypotensive and angiogenic activity in vivo.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Sar-[D-Phe8]-des-Arg9-Bradykinin
  • Note
    Research use only, not for human use.
  • Brief Description
    Potent and selective bradykinin B1 receptor agonist (EC50 = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cleavage. Exhibits hypotensive and angiogenic activity in vivo.
  • Description
    Potent and selective bradykinin B1 receptor agonist (EC50 = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cleavage. Exhibits hypotensive and angiogenic activity in vivo.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Bradykinin Receptor
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    126959-88-4
  • Formula Weight
    975.11
  • Molecular Formula
    C47H66N12O11
  • Purity
    >98% (HPLC)
  • Solubility
    water:2 mg/mL
  • SMILES
    [H]N(C)CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@H](CC1=CC=CC=C1)C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Drapeau et al (1991) Hypotensive effects of Lys-des-Arg9-Bradykinin and metabolically protected agonists of B1 receptors for kinins. J.Pharmacol.Exp.Ther. 259 997 PMID:
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